Endoglandular trophoblast, an alternative route of trophoblast invasion? Analysis with novel confrontation co-culture models
نویسندگان
چکیده
منابع مشابه
An analysis of a mathematical model of trophoblast invasion
We present a mathematical model that describes the initial stages of placental development during which trophoblast cells begin to invade the uterine tissue. We then carry out a mathematical analysis of a simpler submodel that describes the final stages of normal embryo implantation and suggests that as the timescale of interest increases, the dominant migratory mechanism of the trophoblasts sw...
متن کاملEndometrial biology during trophoblast invasion.
Attainment of successful implantation depends upon the synchronized changes in the endometrium before and after the arrival of blastocyst into the uterine cavity. The cues obtained from the receptive endometrium helps in proliferation and differentiation of the trophoblast cells. During the course of invasive differentiation, the trophoblast cells undergo several morphological, biochemical and ...
متن کاملTrophoblast invasion of spiral arteries: a novel in vitro model.
Extravillous trophoblasts invade the uterine wall (interstitial invasion) and the spiral arteries (endovascular invasion), replacing the cells of the vessel wall and creating a high-flow low-resistance vessel. We have developed a novel model to allow the interactions between the invading trophoblast cells and the cells of the spiral artery to be directly examined. Unmodified (non-placental bed)...
متن کاملSignal transduction in trophoblast invasion.
During the first trimester of pregnancy, well-differentiated primary cells of the placenta known as trophoblast cells grow in an invasive and destructive fashion similar to malignancies, but limited in space and time. The comparison of trophoblast cells with their malignant counterpart, human choriocarcinoma cells, offers an attractive model to understand the origin or development of malignant ...
متن کامل(Epi)genetic control of human trophoblast invasion
During pregnancy the placenta is essential for the growing fetus as it provides oxygen and nutrients and accomplishes waste disposal by connecting the maternal and fetal circulations. To form a functional placenta the fetomaternal interface must be properly developed. For this, fetal extravillous trophoblasts need to invade the maternal placental bed thereby remodeling the maternal spiral arter...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2010
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/deq035